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Soo saaraha soo saaraha Cilengitide 98% budo cad CAS NO.188968-51-6 Sawirka
  • Soo saaraha Cilengitide 98% budo cad CAS NO.188968-51-6
  • Soo saaraha Cilengitide 98% budo cad CAS NO.188968-51-6
  • Soo saaraha Cilengitide 98% budo cad CAS NO.188968-51-6

Soo saaraha Cilengitide 98% budo cad CAS NO.188968-51-6

Cilengitide CAS NO: 188968-51-6
Cilengitide waa pentapeptide peptide meerto ah oo u tartameysa isku xigxiga arginine-glycine-aspartate (RGD) peptide.Wuxuu hagaajiyaa isku-xidhka isku-xidhka-dhex-galka ah.Cilengitide waxay si door ah oo wax ku ool ah u xakameysaa alfa v beta 3 beta iyo alfa v 5 integrin oo ay weheliyaan borotiinnada matrixka, sida Vitronectin, Fibronectin, Fibrinogen, vonWillebrandFactor, Osteopontin, iyo kuwa kale.10μMCilengiChemicalbooktide wuxuu si buuxda u xannibayaa ku-xidhka unugyada BAE, BME iyo HUVE ee Vitronectin iyo Fibronectin.Cilengitide waxay u shaqeysaa in vitro unugyada BAE ee lagu sii daaweeyay FGF-2 (ama VEGF-A) ee kolajka saddex-geesoodka ah iyo gel fibrin dhiiga si loo joojiyo angiogenesis leh IC50 ee 15 iyo 8μM, iyo 4 iyo 3μM, siday u kala horreeyaan.Cilengitide waxay joojisaa kororka unugyada, waxay keentaa apoptosis unugyada endothelial, waxayna keentaa kala duwanaanshaha unugga hore ee endothelial.


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Magaca Alaabta Cilengitide
CAS 188968-51-6
caanaha molecular C27H40N8O7
miisaanka kelli 588.66
cufnaanta 1.41±0.1 g/cm3 (La saadaaliyay)
milmay ≥29.43 mg/mL gudaha DMSO;≥22.56 mg/ml ee H2O
Isku-dhafka aysiidhka (pKa) 4.01± 0.10 (La saadaaliyay)
habayn (1)
habayn (1)
habayn (2)

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